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The Uruguay national football team represents Uruguay in international football, and is controlled by the Uruguayan Football Association,

the governing body for football in Uruguay. The Uruguayan team is commonly referred to as La Celeste (The Sky Blue).

Uruguay have won the Copa América 15 times, alongside Argentina the most titles in the history of that tournament. Uruguay's most recent title being the 2011 edition. The team has won the FIFA World Cup twice, including the first World Cup in 1930 as hosts, defeating Argentina 4–2 in the final. Their second title came in 1950, upsetting host Brazil 2–1 in the final match, which has the highest attendance for a football match ever. Uruguay have also won gold medals at the Olympic football tournament twice, in 1924 and 1928. The gold medals received at the 1924 and 1928 Summer Olympics are recognised by FIFA as senior FIFA World Championships

The following 27 players were named in the squad for FIFA World Cup qualifying matches against Peru and Chile on 24 and 29 March 2022 respectively.

Matías Vecino was tested positive for COVID-19 ahead of the match against Peru and was replaced by Fabricio Díaz and Manuel Ugarte in the squad. Facundo Pellistri and Mathías Olivera were released from the squad after the match against Peru.

Caps and goals correct as of 29 March 2022, after the match against Chile